A comprehensive overview of neuropsychiatric symptoms in adolescents with 22q11.2 deletion syndrome.

ABSTRACT:

Background

The 22q11.2 deletion syndrome (22q11DS) is associated with a variety of neuropsychiatric outcomes that vary across deletion carriers. We adopted a dimensional approach to provide a comprehensive overview of neuropsychiatric symptom expression in adolescents with 22q11DS and further our understanding of the observed phenotypical heterogeneity.

Methods

Participants were 208 adolescents with 22q11DS between 10 and 19 years old. Semi-structured clinical interviews and IQ tests were used to quantify symptom expression on multiple symptom dimensions, some reflecting DSM-IV diagnostic domains. We investigated symptom expression in those with and without a formal DSM-IV classification and examined between and within symptom dimensions. We used correlation analyses to expl

SUBMITTER: Selten I 

PROVIDER: S-EPMC11735868 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature