Incompletely closed HIV-1_CH040 envelope glycoproteins resist broadly neutralizing antibodies while mediating efficient HIV-1 entry.

ABSTRACT: HIV-1 envelope glycoproteins (Envs) mediate viral entry and are sole target of neutralizing antibodies. Thus, HIV-1 Envs must maintain a delicate balance between evading neutralizing antibodies while still preserving viral compatibility to mediate entry into target cells. Here, we studied the viral entry effeciency, fitness, and replication of an incompletely closed, transmitted/founder HIV-1 Envs (CH040), which are highly resistant to most bnAbs. CH040 Envs mediated HIV-1 entry to target cells as efficient as other primary Envs, suggesting that antibody resistance and efficient viral entry can develop independently. Expression of CH040 Envs was comparable to other Envs and most CH040 variants that were rationally engineered to increase bnAb resistance showed no significant decrease in the

SUBMITTER: Parthasarathy D 

PROVIDER: S-EPMC11735869 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature