Decoding threat neurocircuitry representations during traumatic memory recall in PTSD.

ABSTRACT: The neurocircuitry mechanisms underlying recall of traumatic memories remain unclear. This study investigated whether traumatic memory recall engages neurocircuitry representations that mirror activity patterns engaged during generalized threat stimulus processing in Post Traumatic Stress Disorder (PTSD). Multivariate pattern analysis was used to train 3 decoders. A "trauma" decoder was trained on fMRI patterns during idiographic trauma versus neutral narratives in a sample of 73 adult women with PTSD. A separate cohort of 125 adult participants completed a reward and threat learning task, from which "shock" and "reward loss" decoders were trained on neural patterns during threat or reward outcome delivery, respectively. These decoders were then cross-tested on the alternative datasets, al

SUBMITTER: Morris KR 

PROVIDER: S-EPMC11735932 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature