Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex.

ABSTRACT: The retrosplenial cortex (RSP) is a complex brain region with multiple interconnected subregions that plays crucial roles in various cognitive functions, including memory, spatial navigation, and emotion. Understanding the afferent and efferent connectivity of the RSP is essential for comprehending the underlying mechanisms of its functions. Here, via viral tracing and fluorescence micro-optical sectioning tomography (fMOST), we systematically investigated the anatomical organisation of the upstream and downstream circuits of glutamatergic and GABAergic neurons in the dorsal and ventral RSP. The cortical connections of the RSP show laminar organisation in which the input neurons are distributed more in the deeper layers of the upstream cortex. Although different types of neurons have simil

SUBMITTER: Li Y 

PROVIDER: S-EPMC11736107 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature