[Ferroptosis-related genes in osteoporosis: a bioinformatics analysis and in vitro study].

ABSTRACT:

Objectives

To explore ferroptosis-related genes in osteoporosis through bioinformatic analysis and in vitro study.

Methods

Osteoporosis-related genes were identified from dataset GSE35958 in the Gene Expression Omnibus database; and the ferroptosis-related genes were identified from the FerrDb database. These were intersected with the differentially expressed genes in GSE35958 to obtain ferroptosis-related genes in osteoporosis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed for the differentially expressed genes. And Spearman correlation and protein-protein interaction network analysis were performed. Then, the hub genes of ferroptosis in osteoporosis were screened by Degree, MNC, EPC, MCC and DMNC in Cytoscap

SUBMITTER: Xia Y 

PROVIDER: S-EPMC11736348 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature