Mapping the spatial atlas of the human bone tissue integrating spatial and single-cell transcriptomics.

ABSTRACT: Bone is a multifaceted tissue requiring orchestrated interplays of diverse cells within specialized microenvironments. Although significant progress has been made in understanding cellular and molecular mechanisms of component cells of bone, revealing their spatial organization and interactions in native bone tissue microenvironment is crucial for advancing precision medicine, as they govern fundamental signaling pathways and functional dependencies among various bone cells. In this study, we present the first integrative high-resolution map of human bone and bone marrow, using spatial and single-cell transcriptomics profiling from femoral tissue. This multi-modal approach discovered a novel bone formation-specialized niche enriched with osteoblastic lineage cells and fibroblasts and unvei

SUBMITTER: Lin W 

PROVIDER: S-EPMC11736439 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature