Characteristics of the immune microenvironment and their clinical significance in lung adenocarcinoma patients with different ALK fusion variants.

ABSTRACT:

Background

The tumor immune microenvironment of anaplastic lymphoma kinase (ALK)-rearranged lung adenocarcinoma (LUAD) stratified by ALK fusion variants is poorly pictured. Hence, in this study, we aim to explore the immune heterogeneity of ALK⁺ LUAD across different ALK fusion variants and further investigate their significance on clinical prognosis.

Methods

A retrospective analysis was conducted on ALK⁺ LUAD patients (N=68). DNA and RNA-based next-generation sequencing (NGS) was performed to clarify the specific ALK fusion variants. Clinical and pathological characteristics were compared between long and short ALK variants. To research the immune heterogeneity, multi-fluorescence was carried out to explore the differences in immune properties, such as

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC11736598 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature