STREM2 in discordant CSF Aβ₄₂ and p-tau181.

ABSTRACT:

Introduction

Little is known about the factors underpinning discordant cerebrospinal fluid (CSF) amyloid beta (Aβ)₄₂ versus p-tau181/Aβ₄₂ or CSF Aβ₄₂ versus Aβ positron emission tomography (PET).

Methods

We stratified 570 non-demented Alzheimer's Disease Neuroimaging Initiative (ADNI) participants by Aβ PET and further by CSF Aβ₄₂ or p-tau181/Aβ₄₂. We used analysis of covariance testing adjusting for covariates, followed by Tukey post hoc pairwise comparisons, to compare CSF soluble triggering receptor expressed on myeloid cells-2 (sTREM2) across four participant groups: CSF+ _Aβ42 with CSF- _p-tau/Aβ42, CSF- _Aβ42 with CSF+ _p-tau/Aβ42, and concordant CSF_Aβ42/CSF_p-

SUBMITTER: Li D 

PROVIDER: S-EPMC11736621 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature