Exploring the relationship between melanopsin gene variants, sleep, and markers of brain health.

ABSTRACT:

Introduction

Melanopsin is a photopigment with roles in mediating sleep and circadian-related processes, which are often disrupted in Alzheimer's disease (AD). Melanopsin also impacts cognition and synaptogenesis. This study investigated the associations between melanopsin genetic variants, sleep, and markers of brain health.

Methods

Linear regression analyses examined the relationship of single-nucleotide polymorphisms (SNPs) within the melanopsin gene (OPN4), with cortical amyloid beta (Aβ), cognition, brain volumes, and self-reported sleep traits in cognitively unimpaired older adults. Further analyses assessed whether sleep traits x OPN4 SNP interactions were associated with markers of brain health.

Results

OPN4 SNPs rs2355009 and rs3740334 we

SUBMITTER: Milligan Armstrong A 

PROVIDER: S-EPMC11736627 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature