A web-based histology atlas for the freshwater sentinel species Daphnia magna.

ABSTRACT: Daphnia are keystone species of freshwater habitats used as model organisms in ecology and evolutionary biology. Their small size, wide geographic distribution, and sensitivity to chemicals make them useful as environmental sentinels in regulatory toxicology and chemical risk assessment. Biomolecular (-omic) assessments of responses to chemical toxicity, which reveal detailed molecular signatures, become more powerful when correlated with other phenotypic outcomes (such as behavioral, physiological, or histopathological) for comparative validation and regulatory relevance. However, the lack of histopathology or tissue phenotype characterization of this species presently limits our ability to assess cellular mechanisms of toxicity. Here, we address the central concept that interpreting aber

SUBMITTER: Ngu MS 

PROVIDER: S-EPMC11736674 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature