Metabolomic Alterations Associated with Phthalate Exposures among Pregnant Women in Puerto Rico.

ABSTRACT: Although phthalate exposure has been linked with multiple adverse pregnancy outcomes, their underlying biological mechanisms are not fully understood. We examined associations between biomarkers of phthalate exposures and metabolic alterations using untargeted metabolomics in 99 pregnant women and 86 newborns [mean (SD) gestational age = 39.5 (1.5) weeks] in the PROTECT cohort. Maternal urinary phthalate metabolites were quantified using isotope dilution high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS), while metabolic profiles in maternal and cord blood plasma were characterized via reversed-phase LC-MS. Multivariable linear regression was used in metabolome-wide association studies (MWAS) to identify individual metabolic features associated with elevated phthala

SUBMITTER: Siwakoti RC 

PROVIDER: S-EPMC11736900 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature