Dose by design: How limits on nicotine flux and puff duration affect the abuse liability of electronic nicotine delivery systems.

ABSTRACT:

Introduction

Electronic nicotine delivery system (ENDS) product standards for nicotine flux (nicotine emitted/second), combined with limiting puff duration, could control nicotine dose and support ENDS regulations. We assessed behavioral and subjective abuse liability indices for ENDS varying in nicotine flux with fixed puff duration among people who smoke.

Methods

This within-subjects study included 32 adults who smoked cigarettes. Own-brand cigarettes (OB) and four unflavored ENDS were evaluated: no-flux (0μg/s), low-flux (36.01μg/s), cigarette-like-flux (90.03μg/s), and high-flux (180.06μg/s), with ENDS puff duration limited to 2s. Outcomes from behavioral economic choice tasks included demand intensity (drug purchase task [DPT]), cross-price elasticity (cross-product DPT

SUBMITTER: Bono RS 

PROVIDER: S-EPMC11736901 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature