Characterization of the genomic landscape in liver oligometastatic NSCLC.

ABSTRACT:

Objectives

Emerging data have shown that local treatment could provide clinical benefit for non-small cell lung cancer (NSCLC) patients with oligometastasis. Liver metastases have the worst prognosis in advanced NSCLC, but the genomic characteristics of liver oligometastasis remain unclear. The aim of our study was to elucidate the molecular features of liver oligometastatic NSCLC.

Methods

Paired liver metastatic tissue samples and peripheral blood from 32 liver oligometastatic NSCLC patients were concurrently collected for comprehensive genomic analysis using next-generation sequencing.

Results

A total of 206 mutated genes in 32 patients were detected, with a median of 4 mutations per sample. The most frequent alterations (> 10%) in liver oligometastasis were TP53 (7

SUBMITTER: Liao R 

PROVIDER: S-EPMC11737069 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature