Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression.

ABSTRACT:

Background

Inclusion Body Myositis is an acquired muscle disease. Its pathogenesis is unclear due to the co-existence of inflammation, muscle degeneration and mitochondrial dysfunction. We aimed to provide a more advanced understanding of the disease by combining multi-omics analysis with prior knowledge. We applied molecular subnetwork identification to find highly interconnected subnetworks with a high degree of change in Inclusion Body Myositis. These could be used as hypotheses for potential pathomechanisms and biomarkers that are implicated in this disease.

Results

Our multi-omics analysis resulted in five subnetworks that exhibit changes in multiple omics layers. These subnetworks are related to antigen processing and presentation, chemokine-mediated signaling, immune

SUBMITTER: Wijnbergen D 

PROVIDER: S-EPMC11737257 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature