A tactfully designed photothermal agent collaborating with ascorbic acid for boosting maxillofacial wound healing.

ABSTRACT: Maxillofacial injuries that may cause severe functional and aesthetic damage require effective and immediate management due to continuous exposure to diverse microbial populations. Moreover, drug resistance, biofilm formation, and oxidative stress significantly impede timely bacterial removal and immune function, making the exploration of advanced materials for maxillofacial wound healing an appealing yet highly challenging task. Herein, a near-infrared photothermal sterilization agent was designed, encapsulated with liposomes and coated with ascorbic acid known for its antioxidant and immune-regulatory functions. The resulting nanoparticles, 4TPE-C6T-TD@AA, effectively neutralize reactive oxygen species generated by lipopolysaccharides, facilitate the conversion of pro-inflammatory M1 mac

SUBMITTER: Qian Y 

PROVIDER: S-EPMC11737384 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature