Chronic implantable flexible serpentine probe reveals impaired spatial coding of place cells in epilepsy.

ABSTRACT: The development of minimally invasive and reliable electrode probes for neural signal recording is crucial for advancing neuroscience and treating major brain disorders. Flexible neural probes offer superior long-term recording capabilities over traditional rigid probes. This study introduces a parylene-based serpentine electrode probe for stable, long-term neural monitoring. Inspired by the flexibility and morphology of snakes, the serpentine design of the probe ensures stable anchorage within the brain tissue during subject movement. The probe features a hydrophilic surface and is combined with a biodegradable silk fibroin-polyethylene glycol coating, significantly enhancing biocompatibility and mitigating inflammatory responses. In vivo experiments demonstrate that these probes e

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11737403 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature