Subchronic inhalation exposure to ultrafine particulate matter alters the intestinal microbiome in various mouse models.

ABSTRACT: Exposure to ultrafine particles (UFPs) has been associated with multiple adverse health effects. Inhaled UFPs could reach the gastrointestinal tract and influence the composition of the gut microbiome. We have previously shown that oral ingestion of UFPs alters the gut microbiome and promotes intestinal inflammation in hyperlipidemic Ldlr^-/- mice. Particulate matter (PM)_2.5 inhalation studies have also demonstrated microbiome shifts in normolipidemic C57BL/6 mice. However, it is not known whether changes in microbiome precede or follow inflammatory effects in the intestinal mucosa. We hypothesized that inhaled UFPs modulate the gut microbiome prior to the development of intestinal inflammation. We studied the effects of UFP inhalation on the gut microbiome and intesti

SUBMITTER: Chang C 

PROVIDER: S-EPMC11737635 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature