Novel Insights into the Aortic Mechanical Properties of Mice Modeling Hereditary Aortic Diseases.

ABSTRACT:

Objective

 Hereditary aortic diseases (hADs) increase the risk of aortic dissections and ruptures. Recently, we have established an objective approach to measure the rupture force of the murine aorta, thereby explaining the outcomes of clinical studies and assessing the added value of approved drugs in vascular Ehlers-Danlos syndrome (vEDS). Here, we applied our approach to six additional mouse hAD models.

Material and methods

 We used two mouse models (Fbn1C1041G and Fbn1mgR ) of Marfan syndrome (MFS) as well as one smooth-muscle-cell-specific knockout (SMKO) of Efemp2 and three CRISPR/Cas9-engineered knock-in models (Ltbp1, Mfap4, and Timp1). One of the two MFS models was subjected to 4-week-long losartan treatment. Per mouse, thre

SUBMITTER: Dubacher N 

PROVIDER: S-EPMC11737803 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature