Occupational lead exposure and amyotrophic lateral sclerosis survival in the Danish National Patient Registry.

ABSTRACT:

Objectives

We investigated the relationship between occupational lead exposure and amyotrophic lateral sclerosis (ALS) survival in Denmark.

Methods

We identified 2,161 ALS cases diagnosed from 1982 to 2013 with at least 5 years of employment history before ALS diagnosis, via the Danish National Patient Registry. Cases were followed until March 2017. We defined lead exposure as never employed in a lead job, ever employed in a lead job, and ever employed in a lead job by exposure probability (<50% vs. ≥50%), excluding jobs held in the 5 years before diagnosis in main analyses. Survival was evaluated using Cox proportional hazards models and stratified by sex and age of diagnosis.

Results

Median age of diagnosis was 63.5 years, and individuals in lead-exposed jobs were d

SUBMITTER: Tang IW 

PROVIDER: S-EPMC11738673 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature