Ferritin nanoparticle-based Nipah virus glycoprotein vaccines elicit potent protective immune responses in mice and hamsters.

ABSTRACT: Nipah virus (NiV) is a zoonotic paramyxovirus in the genus Henipavirus that is prevalent in Southeast Asia. NiV leads to severe respiratory disease and encephalitis in humans and animals, with a mortality rate of up to 75%. Despite the grave threat to public health and global biosecurity, no medical countermeasures are available for humans. Here, based on self-assembled ferritin nanoparticles (FeNPs), we successfully constructed two candidate FeNP vaccines by loading mammalian cells expressing NiV sG (residues 71-602, FeNP-sG) and G_head (residues 182-602, FeNP-G_head) onto E. coli-expressed FeNPs (FeNP-sG and FeNP-G_head, respectively) through Spycatcher/Spytag technology. Compared with sG and G_head alone, FeNP-sG and FeNP-G_head elicited

SUBMITTER: Chen S 

PROVIDER: S-EPMC11738763 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature