A novel vesicular stomatitis virus armed with IL-2 mimic for oncolytic therapy.

ABSTRACT: Oncolytic virus (OV) is increasingly being recognized as a novel vector in cancer immunotherapy. Increasing evidence suggests that OV has the ability to change the immune status of tumor microenvironment, so called transformation of 'cold' tumors into 'hot' tumors. The improved anti-tumor immunity can be induced by OV and further enhanced through the combination of various immunomodulators. The Neo-2/15 is a newly de novo synthesized cytokine that functions as both IL-2 and IL-15. However, it specifically lacks the binding site of IL-2 receptor α subunit (CD25), therefore unable to induce the Treg proliferation. In present study, a recombinant vesicular stomatitis virus expressing the Neo-2/15 (VSV^M51R-Neo-2/15) was generated. Intratumoral delivery of VSV^M51R-Neo-2/15

SUBMITTER: Wu M 

PROVIDER: S-EPMC11738782 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature