Cardioprotective effects of the electrolyte solution sterofundin and the possible underlying mechanisms.

ABSTRACT:

Background

Sterofundin (SF) is one of the most widely used electrolyte solutions in almost all areas of medicine, with particular importance in intensive care. It provides powerful correction of acid-base imbalances, ion fluctuations, and impaired energy metabolism, which are the three most important characteristics after myocardial infarction (MI). However, whether and how SF protects the heart from post-MI damage are largely unknown.

Methods and results

Pretreating mice with SF before MI surgery reduced the number of reactive oxygen species (ROS)-positive and TUNEL-positive cells. As a result, the infarcted area cardiac fibrosis in the MI mice was reduced and cardiac performance in the MI mice improved. Moreover, RNA-seq analysis demonstrated that SF caused the gene expres

SUBMITTER: Chen M 

PROVIDER: S-EPMC11738938 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature