An in-depth study of indolone derivatives as potential lung cancer treatment.

ABSTRACT: Lung cancer is a type of cancer that begins in the lungs and is one of the leading causes of cancer-related deaths worldwide. Herein an attempt to explore the relationship between the properties of indolone derivatives and their anticancer activity was investigated, implementing in silico approaches. Four indolone derivatives with the highest anticancer potential were selected to evaluate their pharmacological properties. The ADMET analysis revealed that these compounds exhibited favourable drug-like properties, meeting nearly all the key pharmacological criteria required for potential therapeutic agents. Molecular docking studies of the most active compounds revealed strong interactions with critical amino acid residues in the PDK1 receptor's binding site, underscoring their potential as

SUBMITTER: Er-Rajy M 

PROVIDER: S-EPMC11739386 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature