Mutual causal effects between immune cells and hepatocellular carcinoma: a Mendelian randomization study.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC), a malignant tumor that seriously endangering health, has aroused widespread concern in the field of public health. Previous researches have noted the relationships between immune cells and HCC, but the causal relationship was uncertain.

Methods

In this study, a bidirectional two sample Mendelian randomization (MR) analysis was utilized to access the causal relationship between immune cell characteristics and HCC. According to the open-access data, we investigated the causal relationship between 731 immune cell characteristics and HCC risk.

Results

After screening by IVW approach, increased levels of 8 immune traits and reduced levels of 7 immune traits could lead to changes in HCC risk. These 15 immune cells were distributed

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11739439 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature