Comparing quantitative imaging biomarker alliance volumetric CT classifications with RECIST response categories.

ABSTRACT:

Purpose

To assess agreement between CT volumetry change classifications derived from Quantitative Imaging Biomarker Alliance Profile cut-points (ie, QIBA CTvol classifications) and the Response Evaluation Criteria in Solid Tumors (RECIST) categories.

Materials and methods

Target lesions in lung, liver, and lymph nodes were randomly chosen from patients in 10 historical clinical trials for various cancers, ensuring a balanced representation of lesion types, diameter ranges described in the QIBA Profile, and variations in change magnitudes. Three radiologists independently segmented these lesions at baseline and follow-up scans using 2 software tools. Two types of predefined disagreements were assessed: Type I: substantive disagreement, where the disagreement between QIBA CTvo

SUBMITTER: Zhao B 

PROVIDER: S-EPMC11739520 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature