Utilizing Patient-Derived Xenografts to Model Precision Oncology for Biliary Tract Cancer.

ABSTRACT:

Purpose

Biliary tract cancers, which are rare and aggressive malignancies, are rich in clinically actionable molecular alterations. A major challenge in the field is the paucity of clinically relevant biliary tract cancer models that recapitulate the diverse molecular profiles of these tumors. The purpose of this study was to curate a collection of patient-derived xenograft (PDX) models that reflect the spectrum of genomic alterations present in biliary tract cancers to create a resource for modeling precision oncology.

Experimental design

PDXs were derived from biliary tract cancer samples collected from surgical resections or metastatic biopsies. Alterations present in the PDXs were identified by whole-exome sequencing and RNA sequencing. PDXs were treated with approved an

SUBMITTER: DiPeri TP 

PROVIDER: S-EPMC11739782 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature