A Phage-Based Approach to Identify Antivirulence Inhibitors of Bacterial Type IV Pili.

ABSTRACT: The increasing threat of antibiotic resistance underscores the urgent need for innovative strategies to combat infectious diseases, including the development of antivirulants. Microbial pathogens rely on their virulence factors to initiate and sustain infections. Antivirulants are small molecules designed to target virulence factors, thereby attenuating the virulence of infectious microbes. The bacterial type IV pilus (T4P), an extracellular protein filament that depends on the T4P machinery (T4PM) for its biogenesis, dynamics and function, is a key virulence factor in many significant bacterial pathogens. While the T4PM presents a promising antivirulence target, the systematic identification of inhibitors for its multiple protein constituents remains a considerable challenge. Here we repo

SUBMITTER: Shimozono TM 

PROVIDER: S-EPMC11739798 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature