Genome-Wide Association Study of Temporomandibular Disorder-Related Pain in Finnish Populations.

ABSTRACT:

Background

Temporomandibular disorders (TMD) are multifactorial musculoskeletal pain and dysfunctions in temporomandibular joints (TMJs) and masticatory muscles. Genetic factors play a role in TMD-related pain, but only a few genome-wide association studies (GWAS) have been conducted.

Objective

The aim of this GWAS was to explore genetic factors associated with painful TMD in Finnish populations.

Methods

Data from two epidemiological surveys, the Northern Finland Birth Cohort 1966 (NFBC1966) and the Health 2000 Survey in Finland, including altogether 468 cases and 6833 controls, were used. Case definition was based on pain on palpation of masticatory muscles and/or TMJs. GWASs of the whole data and stratified by sex were conducted from both cohorts using additive mode

SUBMITTER: Leppilahti JM 

PROVIDER: S-EPMC11740273 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature