Medwakh smoking induces alterations in salivary proteins and cytokine expression: a clinical exploratory proteomics investigation.

ABSTRACT:

Background

Medwakh smoking has radically expanded among youth in the Middle East and around the world. The rising popularity of medwakh/dokha usage is linked to the onset of several chronic illnesses including cardiovascular diseases and cancers. Medwakh smoking is reported to increase the risk of inflammation in the lower respiratory tract owing to oxidative burden. To date, there are no reported studies investigating the impact of medwakh smoking on salivary protein profile. The current study aims to elucidate alterations in the salivary proteome profile of medwakh smokers.

Methods

Saliva samples collected from 33 medwakh smokers and 30 non-smokers were subjected to proteomic analysis using UHPLC-ESI-QTOF-MS. Saliva samples were further subjected to validatory experiments

SUBMITTER: Aghila Rani KG 

PROVIDER: S-EPMC11740365 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature