Investigating the Shared Genetic Architecture Between Psychiatric Disorders and Executive Function.

ABSTRACT:

Background

Evidence for widespread comorbidity of executive dysfunctions with psychiatric disorders suggests common mechanisms underlying their pathophysiology. However, the shared genetic architectures between psychiatric disorders and executive function (EF) remain poorly understood.

Methods

Leveraging large genome-wide association study datasets of European ancestry on bipolar disorder (N = 353,899), major depressive disorder (N = 674,452), and schizophrenia (N = 130,644) from the Psychiatric Genomics Consortium and iPSYCH and a common factor of EF (N = 427,037) from UK Biobank, we systematically investigated the shared genomic architectures between psychiatric disorders and EF with a set of statistical genetic, functional genomic, and gene-lev

SUBMITTER: Zhang S 

PROVIDER: S-EPMC11740799 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature