Diversification of Lipopeptide Analogues Drives Versatility in Biological Activities.

ABSTRACT: Cyclic lipopeptides (CLPs) are potent secondary metabolites with diverse biological functions. Bacillus strains primarily produce CLPs of three key families, namely, iturins, fengycins, and surfactins, each comprising structural variants characterized by a cyclic peptide linked to a fatty acid chain. Despite extensive research on CLPs, the individual roles of these analogues and their proportion in driving biological activity have remained largely overlooked. In this study, we purified and chemically characterized CLP variants from Bacillus velezensis UMAF6639 and tested them individually for their antifungal and plant growth-promoting effects. We isolated 5 fractions containing iturin A analogues (from C₁₃ to C₁₇), 5 fengycin fractions (containing C

SUBMITTER: Grife-Ruiz M 

PROVIDER: S-EPMC11741111 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature