Hypoxia-inducible factor 1α is required to establish the larval glycolytic program in Drosophila melanogaster.

ABSTRACT: The rapid growth that occurs during Drosophila larval development requires a dramatic rewiring of central carbon metabolism to support biosynthesis. Larvae achieve this metabolic state, in part, by coordinately up-regulating the expression of genes involved in carbohydrate metabolism. The resulting metabolic program exhibits hallmark characteristics of aerobic glycolysis and establishes a physiological state that supports growth. To date, the only factor known to activate the larval glycolytic program is the Drosophila Estrogen-Related Receptor (dERR). However, dERR is dynamically regulated during the onset of this metabolic switch, indicating that other factors must be involved. Here we discover that Sima, the Drosophila ortholog of Hif1α, is also essential for establ

SUBMITTER: Heidarian Y 

PROVIDER: S-EPMC11741260 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature