Intestinal RICT-1 regulates the larval germline progenitor pool via the vitellogenin VIT-3 in <i>C. elegans</i>.

ABSTRACT: Populations of proliferating cells such as stem cells and tumors are often nutrient responsive. Highly conserved signaling pathways communicate information about the surrounding environmental, organismal, and cellular nutrient conditions. One such pathway is the Target of Rapamycin (TOR) pathway. The TOR kinase exists in two complexes, TOR complex 1 (TORC1) and TOR complex 2 (TORC2). TORC1 has been researched extensively and its regulation, particularly by amino acids, is well characterized. TORC1 activity promotes both stem cell fate and proliferation in the Caenorhabditis elegans hermaphrodite germline stem cell system to facilitate expansion of the larval germline Progenitor Zone (PZ) pool in response to nutrients. By contrast, a role for TORC2 in germline development has not bee

SUBMITTER: Kloock A 

PROVIDER: S-EPMC11741266 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature