Noise-induced hearing loss enhances Ca²⁺-dependent spontaneous bursting activity in lateral cochlear efferents.

ABSTRACT: Exposure to loud and/or prolonged noise damages cochlear hair cells and triggers downstream changes in synaptic and electrical activity in multiple brain regions, resulting in hearing loss and altered speech comprehension. It remains unclear however whether or not noise exposure also compromises the cochlear efferent system, a feedback pathway in the brain that fine-tunes hearing sensitivity in the cochlea. We examined the effects of noise-induced hearing loss on the spontaneous action potential (AP) firing pattern in mouse lateral olivocochlear (LOC) neurons. This spontaneous firing exhibits a characteristic burst pattern dependent on Ca²⁺ channels, and we therefore also examined the effects of noise-induced hearing loss on the function of these and other ion channels. The burs

SUBMITTER: Hong H 

PROVIDER: S-EPMC11741279 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature