Neural plate pre-patterning enables specification of intermediate neural progenitors in the spinal cord.

ABSTRACT: Dorsal-ventral patterning of neural progenitors in the posterior neural tube, which gives rise to the spinal cord, has served as a model system to understand how extracellular signals organize developing tissues. While previous work has shown that signaling gradients diversify progenitor fates at the dorsal and ventral ends of the tissue, the basis of fate specification in intermediate regions has remained unclear. Here we use zebrafish to investigate the neural plate, which precedes neural tube formation, and show that its pre-patterning by a distinct signaling environment enables intermediate fate specification. Systematic spatial analysis of transcription factor (TF) expression and signaling activity using a reference-based mapping approach shows that the neural plate is partitioned int

SUBMITTER: Nandagopal S 

PROVIDER: S-EPMC11741283 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature