Activity dependent Clustering of Neuronal L-Type Calcium Channels by CaMKII.

ABSTRACT: Neuronal excitation-transcription (E-T) coupling pathways can be initiated by local increases of Ca²⁺ concentrations within a nanodomain close to the L-type voltage-gated Ca²⁺ channel (LTCC). However, molecular mechanisms controlling LTCC organization within the plasma membrane that help creation these localized signaling domains remain poorly characterized. Here, we report that neuronal depolarization increases Ca_V1.3 LTCC clustering in cultured hippocampal neurons. Our previous work showed that binding of the activated catalytic domain of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) to an RKR motif in the N-terminal cytoplasmic domain of Ca_V1.3 is required for LTCC-mediated E-T coupling. We tested whether multimeric CaMKIIα h

SUBMITTER: Yang Q 

PROVIDER: S-EPMC11741290 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature