Homeostatic regulation of a motor circuit through temperature sensing rather than activity sensing.

ABSTRACT: Homeostasis is a driving principle in physiology. To achieve homeostatic control of neural activity, neurons monitor their activity levels and then initiate corrective adjustments in excitability when activity strays from a set point. However, fluctuations in the brain microenvironment, such as temperature, pH, and other ions represent some of the most common perturbations to neural function in animals. Therefore, it is unclear if activity sensing is a universal strategy for different types of perturbations or if stability may arise by sensing specific environmental cues. Here we show the respiratory network of amphibians mounts a fast homeostatic response to restore motor function following inactivity caused by cooling over the physiological range. This response was not initiated by inact

SUBMITTER: Cannon D 

PROVIDER: S-EPMC11741314 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature