Transcriptional Integration of Meiotic Prophase I Progression and Early Oocyte Differentiation.

ABSTRACT: Female reproductive senescence results from the regulated depletion of a finite pool of oocytes called the ovarian reserve. This pool of oocytes is initially established during fetal development, but the oocytes that comprise it must remain quiescent for decades until they are activated during maturation in adulthood. In order for developmentally competent oocytes to populate the ovarian reserve they must successfully initiate both meiosis and oogenesis. As the factors that regulate the timing and fidelity of these early events remain elusive, we assessed the precise function and timing of the transcriptional regulator TAF4b during meiotic prophase I progression in mouse fetal oocytes. Compared to matched controls, E14.5 Taf4b-deficient oocytes enter meiosis I in a timely manner how

SUBMITTER: Abt KM 

PROVIDER: S-EPMC11741336 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature