Secreted Frizzled-Related Protein 1a regulates hematopoietic development in a dose-dependent manner.

ABSTRACT: Hematopoietic stem and progenitor cells (HSPCs) arise only during embryonic development, and their identity specification, emergence from the floor of the dorsal aorta, and proliferation are all tightly regulated by molecular mechanisms such as signaling cues. Among these, Wnt signaling plays an important role in HSPC specification, differentiation, and self-renewal, requiring precise modulation for proper development and homeostasis. Wnt signaling is initiated when a Wnt ligand binds to cell surface receptors such as those encoded by the frizzled gene family, activating intracellular signaling pathways that regulate gene expression. Secreted frizzled-related proteins (Sfrps) are known modulators of Wnt signaling, acting as both agonists and antagonists of this pathway. Yet, in v

SUBMITTER: Ide AD 

PROVIDER: S-EPMC11741364 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature