Decoding Gene Networks Controlling Hypothalamic and Prethalamic Neuron Development.

ABSTRACT: Neuronal subtypes derived from the embryonic hypothalamus and prethalamus regulate many essential physiological processes, yet the gene regulatory networks controlling their development remain poorly understood. Using single-cell RNA- and ATAC-sequencing, we analyzed mouse hypothalamic and prethalamic development from embryonic day 11 to postnatal day 8, profiling 660,000 cells in total. This identified key transcriptional and chromatin dynamics driving regionalization, neurogenesis, and differentiation. This identified multiple distinct neural progenitor populations, as well as gene regulatory networks that control their spatial and temporal identities, and their terminal differentiation into major neuronal subtypes. Integrating these results with large-scale genome-wide association study

SUBMITTER: Kim DW 

PROVIDER: S-EPMC11741371 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature