Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons.

ABSTRACT: Mitochondrial ATP production and calcium buffering are critical for metabolic regulation and neurotransmission making the formation and maintenance of the mitochondrial network a critical component of neuronal health. Cortical pyramidal neurons contain compartment-specific mitochondrial morphologies that result from distinct axonal and dendritic mitochondrial fission and fusion profiles. We previously showed that axonal mitochondria are maintained at a small size as a result of high axonal mitochondrial fission factor (Mff) activity. However, loss of Mff activity had little effect on cortical dendritic mitochondria, raising the question of how fission/fusion balance is controlled in the dendrites. Thus, we sought to investigate the role of another fission factor, fission 1 (Fis1), on mitoc

SUBMITTER: Strucinska K 

PROVIDER: S-EPMC11741399 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature