Continuous cell type diversification throughout the embryonic and postnatal mouse visual cortex development.

ABSTRACT: The mammalian cortex is composed of a highly diverse set of cell types and develops through a series of temporally regulated events that build out the cell type and circuit foundation for cortical function. The mechanisms underlying the development of different cell types remain elusive. Single-cell transcriptomics provides the capacity to systematically study cell types across the entire temporal range of cortical development. Here, we present a comprehensive and high-resolution transcriptomic and epigenomic cell type atlas of the developing mouse visual cortex. The atlas was built from a single-cell RNA-sequencing dataset of 568,674 high-quality single-cell transcriptomes and a single-nucleus Multiome dataset of 194,545 high-quality nuclei providing both transcriptomic and chromatin acce

SUBMITTER: Gao Y 

PROVIDER: S-EPMC11741437 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature