Subcontinental Genetic Diversity in the <i>All of Us</i> Research Program: Implications for Biomedical Research.

ABSTRACT: The All of Us Research Program (All of Us) seeks to accelerate biomedical research and address the underrepresentation of minorities by recruiting over one million ethnically diverse participants across the United States. A key question is how self-identification with discrete, predefined race and ethnicity categories compares to genetic diversity at continental and subcontinental levels. To contextualize the genetic diversity in All of Us, we analyzed ~2 million common variants from 230,016 unrelated whole genomes using classical population genetics methods, alongside reference panels such as the 1000 Genomes Project, Human Genome Diversity Project, and Simons Genome Diversity Project. Our analysis reveals that participants within self-identified race and ethnicity gr

SUBMITTER: Gouveia MH 

PROVIDER: S-EPMC11741438 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature