Brain morphometry, stimulation charge, and seizure duration in electroconvulsive therapy.

ABSTRACT:

Background

Electroconvulsive therapy (ECT) is a well-established and effective treatment for severe depression and other conditions. Though ECT induces a generalized seizure, it is unclear why seizures are therapeutic. This study analyzed relationships between pre-treatment brain morphology, stimulation dose, and seizure duration to better understand ECT-induced seizures.

Methods

Pre-existing MRI data were analyzed from four cohorts with treatment refractory depression undergoing right unilateral (RUL) ECT (n=166). Regional brain morphometry and magnitude of electrical current (|E|) were analyzed, along with seizure duration and stimulation charge at seizure threshold (ECT1) and 6x seizure threshold (ECT2&3). Linear models controlled for age, sex, and cohort, corrected using

SUBMITTER: Leaver AM 

PROVIDER: S-EPMC11741464 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature