Evaluating the biomedical and behavioural drivers of HIV-1 incidence decline in adolescent girls and young women in Uganda: A mathematical modelling study.

ABSTRACT:

Background

Recent declines in HIV incidence among adolescent girls and young women (AGYW) in Africa are often attributed to the expansion of biomedical interventions such as antiretroviral therapy and voluntary medical male circumcision. However, changes in sexual behaviour may also play a critical role. Understanding the relative contributions of these factors is essential for developing strategies to sustain and further reduce HIV transmission.

Methods

We conducted a mathematical modelling study of data from the Rakai Community Cohort Study (RCCS), an open, population-based cohort of 15- to 49-year-olds in 30 communities in Rakai, Uganda, to investigate the biomedical and behavioural drivers of HIV incidence decline in AGYW (15-24 years of age). We estimated changes in the

SUBMITTER: Akullian A 

PROVIDER: S-EPMC11741483 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature