Sex differences in the association between age-related decline in blood pressure and decline in cognition: A prospective cohort study.

ABSTRACT:

Background

Both high and declining blood pressure (BP) are associated with cognitive decline risk in older adults. In late-life, women have higher rates of hypertension, experience faster cognitive decline, and represent two-thirds of individuals with Alzheimer's disease dementia. However, sex differences in the association between BP decline and cognitive decline are unknown.

Methods

Data were analyzed from 4719 older adults without known baseline dementia (mean age = 76.7 [SD = 7.7] years; 74% women) enrolled in one of five US-based prospective community-based cohort studies, followed annually for up to 31 years (mean = 8.7 [SD = 5.7] years). A 19-test cognitive battery, yielding composite global and five domain-specific scores, and BP were assessed annually. Bivariate mix

SUBMITTER: Baumgartner NW 

PROVIDER: S-EPMC11741488 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature