Stereotyped and specific gene expression programs in human innate immune responses to bacteria.

ABSTRACT: The innate immune response is crucial for defense against microbial pathogens. To investigate the molecular choreography of this response, we carried out a systematic examination of the gene expression program in human peripheral blood mononuclear cells responding to bacteria and bacterial products. We found a remarkably stereotyped program of gene expression induced by bacterial lipopolysaccharide and diverse killed bacteria. An intricately choreographed expression program devoted to communication between cells was a prominent feature of the response. Other features suggested a molecular program for commitment of antigen-presenting cells to antigens captured in the context of bacterial infection. Despite the striking similarities, there were qualitative and quantitative differences in the

SUBMITTER: Boldrick JC 

PROVIDER: S-EPMC117415 | biostudies-literature | 2002 Jan

REPOSITORIES: biostudies-literature