Effect of Oxygen Saturation Targets on Neurologic Outcomes after Cardiac Arrest: A Secondary Analysis of the PILOT Trial.

ABSTRACT:

Background

More than 600,000 adults in the United States experience a cardiac arrest each year. After resuscitation from cardiac arrest, most patients receive mechanical ventilation. The oxygenation target that optimizes neurologic outcomes after cardiac arrest is uncertain.

Research question

After cardiac arrest, does a lower oxygen saturation (SpO₂) target improve neurologic outcomes compared to a higher SpO₂ target?

Study design and methods

We conducted a secondary analysis of patients who experienced a cardiac arrest before enrollment in the Pragmatic Investigation of optimal Oxygen Targets (PILOT) trial. The PILOT trial assigned critically ill adults receiving mechanical ventilation to a lower (88-92%), intermediate, (92-96%), or higher (96-

SUBMITTER: DeMasi SC 

PROVIDER: S-EPMC11741503 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature