Exploration and verification of the therapeutic mechanism of shenfu injection in sepsis-induced myocardial injury.

ABSTRACT:

Background

Shenfu injection (SFI), derived from a traditional Chinese medicine (TCM) prescription, is an effective drug for the treatment of sepsis-induced myocardial injury (SIMI) with good efficacy, but its exact therapeutic mechanism remains unclear.

Methods

SwissTargetPrediction and GeneCards database were used to obtain relevant targets for SFI and SIMI. STRING 11.5 and MCODE were used to analyse potential therapeutic targets for SFI. DAVID 6.8 database was used to perform enrichment analysis. In addition, the SIMI model was constructed by cecal ligation and puncture (CLP) on Sprague Dawley rats and the related protein expression levels were verified by AutoDock Vina 1.1.2 and experiment.

Results

SFI has a total of 10 main active compounds and treats SIMI through

SUBMITTER: Yuan HJ 

PROVIDER: S-EPMC11741597 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature