Structural connectivity changes in focal epilepsy: Beyond the epileptogenic zone.

ABSTRACT:

Objective

Epilepsy is recognized increasingly as a network disease, with changes extending beyond the epileptogenic zone (EZ). However, more studies of structural connectivity are needed to better understand the behavior and nature of this condition.

Methods

In this study, we applied differential tractography, a novel technique that measures changes in anisotropic diffusion, to assess widespread structural connectivity alterations in a total of 42 patients diagnosed with medically refractory epilepsy (MRE), including 27 patients with focal epilepsy and 15 patients with multifocal epilepsy that were included to validate our hypothesis. All patients were compared individually to an averaged database constructed from 19 normal controls regressed by age and sex.

Results

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SUBMITTER: Barrios-Martinez JV 

PROVIDER: S-EPMC11741924 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature